The BBB
The Blood Brain Barrier (BBB) is a complex interface between blood and brain protecting this one by many mechanisms. Highly specific in Human, it is the major entrave to the development of new molecules.
The Blood Brain Barrier (BBB) is a complex interface between blood and brain protecting this one by many mechanisms. Highly specific in Human, it is the major entrave to the development of new molecules.
The Physiologically-Based Pharmacokinetic (PBPK) model is an essential tool to predict drug exposure. It incorporates physiological but also drug-specific parameters.
Human brain tissue possess characteristics and functionalities unique to Human and unique to each individual: specificity, composition, content of proteins, lipids,...
All our in vitro models are exclusively based on fresh Human brain cells and tissues, to get closer to the reality.
We can predict your molecule concentration in the human brain parenchyma from preclinical stages data.