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BRAINPLOTTING

Human Data from preclinical stages

The BBB

The Blood Brain Barrier (BBB) is a complex interface between blood and brain protecting this one by many mechanisms. Highly specific in Human, only a few molecules can pass through.

PBPK Modelisation

The Physiologically-based pharmacokinetic (PBPK) model is an important tool to predict drug exposure. It incorporates physiological but also drug-specific parameters.

Human Tissue

Protein specificity, lipid composition, ... Human brain tissue possess characteristics and functionalities unique to Human and specific to each individual.